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In dealing with the endocrine factor in rheumatism Brown thinks we may confine our attention to the ovaries and thyroid, the latter especially. He agreed with the pioneer Hertoghe that it was most important to look for evidences of hypothyroidism. Thyroid instability is the important thing, and it is possible also that spurts of hyperthyroidism on a background of hypothyroidism might be present in some cases. Lack of iodine is a feature in both, and iodine is useful both for goiter and rheumatism. Tonsillar sepsis may often be associated with thyroid derangement. It is possible that studies of the blood-sugar
Endocrine Factor in Rheumatism.. Ann Intern Med. ;2:230. doi: 10.7326/0003-4819-2-2-230_1
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Published: Ann Intern Med. 1928;2(2):230.
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