JOHN C. KRANTZ JR.
Recent literature indicates the existence of a hyperglycemic principle in the blood of diabetic animals. Thus L. Kepinov and S. Petit-Dutailis (1) showed the existence of a principle in diabetic blood which acts antagonistically to the action of insulin. These investigators depancreatized dogs to the extent that a normal blood sugar was just maintained: in these dogs the injection of large quantities of diabetic blood produced a hyperglycemia which lasted for several days. Depisch and Hasenohrl (2) found the serum from a case of diabetes with a paranephritic abscess to have an insulin-inhibiting action on rabbits. Serum from cases
KRANTZ JC. Diabetes Mellitus: A Further Study of the Etiology of the Disease1. Ann Intern Med. ;2:1209–1215. doi: 10.7326/0003-4819-2-11-1209
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Published: Ann Intern Med. 1929;2(11):1209-1215.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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