R. S. ROWLAND, M.D.
Christian's Syndrome of Defects in Membranous Bones, Exophthalmos and Diabetes Insipidus is a rare syndrome of early childhood.
Recently, (Archives of Internal Medicine, November 1928), I discussed fourteen cases of this condition, twelve that had been reported in the literature and two new ones of my own, bringing them into relationship with several similar cases that had been recorded as a special form of xanthoma.
The entire group I regarded as a generalized xanthomatosis, representing pathologic lipoid storage, or lipoid cell hyperplasia, of the reticulo-endothelial system.
The pathologic change in these cases occurred as hyperplastic plaques and nodules arising from
ROWLAND RS. Christian's Syndrome and Lipoid Cell Hyperplasias of the Reticulo-Endothelial System. Ann Intern Med. ;2:1277–1299. doi: 10.7326/0003-4819-2-12-1277
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Published: Ann Intern Med. 1929;2(12):1277-1299.
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