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In an article written in 1927 by Noguchi for Cecil's Textbook of Medicine he states that yellow fever is caused by a specific micro-organism, Leptospira icteroides, first isolated in 1918, during an epidemic of yellow fever in Quayaquil, Ecuador. The organism is present in the circulating blood of the patient at least during the first three or four days of the illness, and is occasionally found in the liver or kidney at autopsy when the patient had died early in the disease. It can be isolated either from the blood of yellow fever patients during the febrile stage, or from
THE PASSING OF THE NOGUCHI ORGANISM OF YELLOW FEVER. Ann Intern Med. ;3:70–72. doi: 10.7326/0003-4819-3-1-70
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Published: Ann Intern Med. 1929;3(1):70-72.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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