In discussing the nature of Pernicious Anemia, we wish to confine ourselves strictly to the idiopathic anemia described by Addison and later by Biermer, and differentiate it as sharply as possible from other anemias with similar blood pictures.
In Addisonian Anemia three organ systems are dominantly affected, the gastro-intestinal tract, the blood, and the central nervous system.
The lesions in the gastrointestinal tract are glossitis, and an achylia gastrica associated with an atrophy of the gastric mucosa. Both pepsin and HCl are lacking in the gastric secretions, and injections of histamine do not lead to any secretion of acid as
WEST R. Pernicious Anemia as a Deficiency Disease1. Ann Intern Med. 1929;3:132–136. doi: 10.7326/0003-4819-3-2-132
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Published: Ann Intern Med. 1929;3(2):132-136.
Hematology/Oncology, Red Cell Disorders.
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