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Gruhzit has studied the pathologic changes produced at the point of injection in animals of the main types of antisyhilitic drugs. From this study it appears that the administration of the arsphenamine type of drugs intramuscularly invariably results in the formation of sterile abscesses, the healing of which is slow. At the end of eight weeks the healing has shown little progress. In this respect, sulpharsphenamine causes just as extensive an injury as neoarsphenamine. The mercury compounds produce the same type of injury only in a lesser degree. The injured areas, however, are more rapidly absorbed and fibrosed, especially when
Local Microscopic Changes Following the Administration of Antisyphilitic Drugs.. Ann Intern Med. 1929;3:285–286. doi: 10.7326/0003-4819-3-3-285
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Published: Ann Intern Med. 1929;3(3):285-286.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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