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Following Castle's demonstration that the stomach of normal individuals secreted a substance which could develop a blood-maturing principle from meat, Sturgis, Isaacs and Sharp began experiments to determine the nature of the material in the stomach which could produce a hematopoietically active substance. Sharp, on the basis of an original theory, decided that the feeding of stomach should have the same effect on patients with pernicious anemia as liver. A preparation was made by dessicating fresh whole hog stomach and defatting with petroleum benzine, so that 30 gm. of the final material represented 218 gm. of the fresh tissue. This
Dessicated Stomach in the Treatment of Pernicious Anemia. Ann Intern Med. ;3:386–387. doi: 10.7326/0003-4819-3-4-386
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Published: Ann Intern Med. 1929;3(4):386-387.
Gastroenterology/Hepatology, Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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