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These workers studied the peripheral action of ephedrine and pseudoephedrine on rabbit bronchial muscle, using their modified method of the isolated lung perfusion described by Sollmann and Van Oettingen. The response of the bronchial muscle varied with the dosage. Perfusion with highly diluted concentrations, such as 1:1,000,000 to 1:5,000,000 in 6 experiments produced a definite bronchial dilatation, and the effect of 1:1,000,000 was more distinct than that of the more dilute solution. Comparing this effect with the action of ephedrine on the circulation and other smooth muscles the bronchial dilation is probably a sympathetic reaction. Perfusion with moderate concentrations of
Action of Ephedrine and Pseudoephedrine Upon the Bronchial Muscle.. Ann Intern Med. 1930;3:1060. doi: 10.7326/0003-4819-3-10-1060_1
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Published: Ann Intern Med. 1930;3(10):1060.
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