MATTHEW C. RIDDLE, M.D.
The similarity of the symptoms of hunger, headache, restlessness and sweating seen in early remission in patients with pernicious anemia after liver therapy and in hypoglycemia has been mentioned by Blotner and Murphy.1 Investigating the blood sugar reducing properties of whole liver and liver extracts, these authors find an insulin-like, blood sugar reducing action common to whole liver and certain extracts of liver which are in-effective in the treatment of pernicious anemia. The liver extract fraction (G) of Cohn2 which is effective in the treatment of pernicious anemia, they find does not exhibit this blood sugar reducing effect. In
RIDDLE MC. The Blood Sugar During Remission in Pernicious Anemia. Ann Intern Med. ;3:1097–1103. doi: 10.7326/0003-4819-3-11-1097
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Published: Ann Intern Med. 1930;3(11):1097-1103.
Hematology/Oncology, Red Cell Disorders.
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