J. H. MEANS, M.D., F.A.C.P.
As a result of studies on the action of iodine in exophthalmic goiter begun in the spring of 1923, when Plummer first described its characteristic effect, and continued ever since, we have come to certain conclusions about indications for treatment which seem sufficiently definite to warrant review. What iodine does has become clear; how it does it remains a mystery.
The most characteristic phenomena which this element or its salts produces in persons suffering from real Graves' disease are the rapid amelioration of symptoms, especially the nervous, and the fall in pulse rate and basal metabolic rate which occurs, with
MEANS JH. The Use of Iodine in Exophthalmic Goiter1. Ann Intern Med. ;4:117–121. doi: 10.7326/0003-4819-4-2-117
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Published: Ann Intern Med. 1930;4(2):117-121.
Endocrine and Metabolism, Thyroid Disorders.
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