A. B. BROWER, M.D., F.A.C.P.
"The leading and characteristic features of the morbid state to which I would direct attention are anemia, general languor and debility, remarkable feebleness of heart action, irritability of the stomach, and a peculiar change in color of the skin occurring in connection with diseased condition of the suprarenal capsule." This original description of adrenal insufficiency by Addison1 remains classical.
If a patient presents these clinical phenomena and at autopsy shows bilateral destructive changes of the adrenals, there can be no doubt as to the diagnosis. On the other hand, if a patient presents the clinical manifestations of Addison's disease, and
BROWER AB. Unusual Addison's Syndromes12. Ann Intern Med. ;4:166–175. doi: 10.7326/0003-4819-4-2-166
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Published: Ann Intern Med. 1930;4(2):166-175.
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