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Sodium salicylate is commonly used in the treatment of infections, especially those presumed to be due to invasion by streptococcus. The old idea that acute rheumatic fever is due to infection by streptococcus, and the recently developed conception that the disease is involved in a process of allergy to streptococcus, stimulated this study of sodium salicylate in relation to allergy to streptococcus. Rabbits, inoculated with cultures of a strain of S. hemolyticus of low virulence, were used for this study. Following the intra-cuticular injection of streptococci, purulent arthritis invariably resulted and persisted until the death of the animal. In the
Effect of Sodium Salicylate on Intradermal Reactions of Rabbits.. Ann Intern Med. 1930;4:194. doi: 10.7326/0003-4819-4-2-194_2
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Published: Ann Intern Med. 1930;4(2):194.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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