NORMAN M. KEITH, M.D.; JAMES W. KERNOHAN, M.B.
Bright, 100 years ago, showed that there was a relationship between pathologic changes in the kidney and diffuse vascular disease. Forty years later, Johnson, Gull, and Sutton demonstrated in cases similar to those cited by Bright that there might also be injury to the peripheral vessels including the arterioles. Thirty-five years ago Allbutt showed clinically and pathologically that diffuse vascular disease with hypertension, without renal lesions, and without gross peripheral vascular lesions, could exist.
Since that time, of course, many observers have wondered as to the cause of hypertension, and there have been theories that the thyroid gland and the
NORMAN M. KEITH, JAMES W. KERNOHAN. Some Newer Aspects in the Problem of Essential Hypertension(Some Newer Aspects in the Problem of Essential Hypertension*). Ann Intern Med. 1930;4:217–221. doi: 10.7326/0003-4819-4-3-217
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Published: Ann Intern Med. 1930;4(3):217-221.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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