B. J. CLAWSON, M.D.
The microscopic lesions found in acute rheumatic fever have quite generally come to be considered characteristic (not specific) anatomic features of the disease both by those who believe the streptococcus to be the exciting agent and by those who believe that the disease is produced by an unknown virus. The lesions show mononuclear and multinucleated cells with vesicular or hyperchromatic nuclei (the so-called Aschoff cells), lymphocytes, plasma cells, eosinophiles, and a varying number of polymorphonuclear leucocytes.
Such inflammation, either in nodules or in irregular diffuse arrangement, has been described as occurring in the subcutaneous tissues, joints, tendons, galea aponeurotica, diaphragm
CLAWSON BJ. The Relation of Experimental Rheumatoid Inflammation to Allergy1†. Ann Intern Med. 1930;4:433–439. doi: 10.7326/0003-4819-4-5-433
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Published: Ann Intern Med. 1930;4(5):433-439.
Rheumatoid Arthritis, Rheumatology.
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