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The purpose of this investigation was to observe the alterations in the blood chemistry associated with malignant disease, and to determine the value of such changes in the diagnosis of human cancer. Freund (1885) and Trinkler (1890) found in cancer patients a low tolerance for sugar and claimed that the carbohydrate tolerance test was of diagnostic value in cancer. Rohdenburg, Bernard, and Krehbiel (1919) studied the sugar tolerance in cancer patients and found a low tolerance for sugar in all cancer patients examined, but as their series was small, they did not base any contentions on their findings. In the
Changes in the Blood Chemistry in Malignant Disease with Special Reference to Carbohydrate Tolerance and Alkalosis.. Ann Intern Med. ;4:506. doi: 10.7326/0003-4819-4-5-506
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Published: Ann Intern Med. 1930;4(5):506.
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