GEORGE E. BROWN, M.D.; PAUL A. O'LEARY, M.D.; ALFRED W. ADSON, M.D.
Scleroderma is the term that has been applied to a syndrome characterized by induration, pigmentation, and sclerosis of the skin, associated with loss of weight, asthenia, arthritis, atrophy of muscles and other symptoms, depending on the degree and extent of the hidebinding. Cases of the disease may be divided into two groups: the diffuse or generalized form, and the localized form known as morphea or circumscribed scleroderma. The group known as morphea will be eliminated from this report.
The onset of the diffuse form of scleroderma varies. It may be ushered in with symptoms of arthralgia, malaise, loss of weight
BROWN GE, O'LEARY PA, ADSON AW. Diagnostic and Physiologic Studies in Certain Forms of Scleroderma1. Ann Intern Med. 1930;4:531–554. doi: 10.7326/0003-4819-4-6-531
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Published: Ann Intern Med. 1930;4(6):531-554.
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