ROBERT C. MOEHLIG, M.D.; EUGENE A. OSIUS, M.D.
Experimental production of arteriosclerosis in rabbits has been accomplished by several workers. Anitschkow and Chalatow1, Bailey2 and others, have used various sorts of diets high in fats or fat-like substances to produce these changes.
Certain facts led us to approach the problem from a new angle. The relationship between the pituitary gland and fat and carbohydrate metabolism suggested that the pituitary secretion might be concerned in arteriosclerosis.
While the exact pathogenesis of arteriosclerosis is somewhat in doubt, nevertheless the cholesterol infiltration of the blood vessels is definitely established.
The importance of the suprarenal cortex in cholesterol metabolism is well recognized.
MOEHLIG RC, OSIUS EA. The Pituitary Factor in Arteriosclerosis1 Its Experimental Production in Rabbits. Ann Intern Med. 1930;4:578–592. doi: 10.7326/0003-4819-4-6-578
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Published: Ann Intern Med. 1930;4(6):578-592.
Endocrine and Metabolism, Neurology, Pituitary Disorders.
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