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The present era in cancer research dates back somewhat more than 30 years. In this paper I must limit myself to a rapid survey of the advances made during this period and to an indication of how I believe the isolated facts thus accumulated can be combined into a consistent theory of cancer.
To state the essential fact, cancer cells are cells which were originally, either ordinary tissue or embryonal cells, and which, under the influence of environmental stimuli, acting in combination with hereditary factors, assume an increased intensity of proliferation; in some cases this proliferation is combined with increased
LOEB L. The Biology and Etiology of Cancer12. Ann Intern Med. ;4:669–675. doi: 10.7326/0003-4819-4-7-669
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Published: Ann Intern Med. 1931;4(7):669-675.
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