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The investigation of the action of potassium salts on the heart dates from the time of Ringer's classical experiments on the frog heart. He proved, irrespective of osmotic tension, the necessity of sodium potassium and calcium ions in a balanced solution. Hering stopped paroxysmal ventricular tachycardia and ventricular fibrillation in the dog, and many investigators have similarly obtained immediate cessation of both auricular and ventricular ectopic rhythms by intravenous or intracardiac injections of solutions of potassium chloride. Wiggers suggested the possibility of its therapeutic use in ventricular fibrillation of accidental electrocution. It thus seemed reasonable to attempt to disturb the
The Therapeutic Use of Potassium in Certain Cardiac Arrhythmias.. Ann Intern Med. 1931;4:846–847. doi: 10.7326/0003-4819-4-7-846_2
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Published: Ann Intern Med. 1931;4(7):846-847.
Cardiology, Rhythm Disorders and Devices.
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