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In a number of papers Duval and Hibbard have reported the production in rabbits of an acute glomerulopephritis following the intravenous injection of the bacteria-free toxic principle of Streptococcus scarlatinae, which they characterized as endotoxic in nature. Their histopathological material was considered analogous to that observed in human scarlatinal glomerulonephritis. These experiments were repeated by Reith, Warfield, and Enzer, who concluded that identical renal lesions occurred in normal rabbits as well as in those injected with suspensions of non-scarlatinal streptococci. They averred that none of the renal lesions produced were typical of human acute glomerulonephritis. On the other hand, Rich,
Pathological Lesions Produced in Rabbits Following Intravenous Injection of Concentrated Scarlet Fever Toxin.. Ann Intern Med. ;4:847–848. doi: 10.7326/0003-4819-4-7-847
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Published: Ann Intern Med. 1931;4(7):847-848.
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