KENNETH C. SMITHBURN, M.D.; L. G. ZERFAS, M.D.
In the study of more than 150 cases of primary and secondary anemia, it has been frequently observed that fevers and intoxications of various origins have apparently retarded, interrupted, or prevented the hematopoietic response during active treatment. Minot1 has pointed out that the hematopoietic response in cases of pernicious anemia treated with liver extract may be slight or delayed in the presence of complications. Whipple and his associates2 have observed that infections and intoxications may retard the increase in hemoglobin production in experimental anemias.
The following patient, who came under our observation, demonstrates in a striking manner the effect of
SMITHBURN KC, ZERFAS LG. The Inhibitory Action of Infection and Fever on the Hematopoietic Response in a Case of Pernicious Anemia1. Ann Intern Med. ;4:1108–1111. doi: 10.7326/0003-4819-4-9-1108
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Published: Ann Intern Med. 1931;4(9):1108-1111.
Hematology/Oncology, Infectious Disease, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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