ELWOOD A. SHARP, M.D.; RICHARD M. MCKEAN, M.D.; ELMORE C. VONDER HEIDE, M.D.
In September, 1929, one of us (E. A. S.)1 reported the presence of an antianemic factor in desiccated hog stomach. The clinical evaluation of these stomach preparations in pernicious anemia was described by Sturgis and Isaacs2, and later by Renshaw3. Subsequently, the value of stomach tissue in this disease was confirmed by Connor4, Wilkinson5, Geuting6, Godel7, Jagic and Klima8 and others, working independently.
Since the ratio of dried gastric tissue to raw substance is low, thereby entailing the daily use of 20 to 40 gm. of desiccated substance to induce a remission in pernicious anemia during a severe relapse, efforts
SHARP EA, MCKEAN RM, VONDER HEIDE EC. Pernicious Anemia: The Behavior of Various Extracts of Stomach and Duodenum Used to Induce Remissions12. Ann Intern Med. ;4:1282–1286. doi: 10.7326/0003-4819-4-10-1282
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Published: Ann Intern Med. 1931;4(10):1282-1286.
Gastroenterology/Hepatology, Hematology/Oncology, Red Cell Disorders.
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