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As previously shown by Hartman and his associates, cortin, a substance obtained from the adrenal cortex, enables adrenal-ectomized cats and rats to survive indefinitely. If Addison's disease is due to a deficiency of cortin the injection of this substance should ameliorate the disease. A patient, a man 24 years old, who was apparently moribund, has been kept alive for more than five months by this method. When first seen he was in shock with a pulse pressure of 50/20 mm. He was cold and drowsy, complained that his extremities felt numb, and talked irrationally. Twenty-four hours after admission, 5 cc.
The Use of Cortin in Addison's Disease.. Ann Intern Med. 1931;4:1612. doi: 10.7326/0003-4819-4-12-1612_1
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Published: Ann Intern Med. 1931;4(12):1612.
Adrenal Disorders, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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