FRED M. SMITH, M.D., F.A.C.P.; W. D. PAUL, M.D.
Various explanations have been given for the pain of peptic ulcer. In general, however, there are two prevailing conceptions. One is primarily concerned with the irritating action of the hydrochloric acid of the gastric juice on the exposed nerve endings in the ulcer. The other places the emphasis on the altered motor function as represented by spasm, particularly of the pylorus or pyloric sphincter, hyperperistalsis or a combination of these factors producing increased gastric tension.
Talma1 was one of the first to study the mechanism of gastric pain by the introduction of acid into the stomach. Bönninger,2 Heinecke and von
SMITH FM, PAUL WD. Studies on the Mechanism of the Pain of Peptic Ulcer12. Ann Intern Med. 1931;5:14–22. doi: 10.7326/0003-4819-5-1-14
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Published: Ann Intern Med. 1931;5(1):14-22.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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