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It has been known for some time that the administration of phosphorus to growing children causes the freshly forming trabeculae at the ends of the shafts of the long bones to multiply and become closely packed together, thus producing a dense shadow. After the administration of phosphorus has been suspended for the proper length of time this shadow takes the form of a band which appears displaced toward the shaft since the most recently formed bone at the extremity of the shaft is less dense. In four cases of chronic lead poisoning studied by the authors similar shadows were found,
Shadows Produced by Lead in the X-Ray Pictures of the Growing Skeleton.. Ann Intern Med. ;5:74–75. doi: 10.7326/0003-4819-5-1-74_2
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Published: Ann Intern Med. 1931;5(1):74-75.
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