WILLIAM S. MIDDLETON, M.D., F.A.C.P.
The bedside-necropsy correlation of disease was in a considerable measure responsible for the dawn of modern clinical medicine in the late eighteenth and the early nineteenth centuries. In a majority of instances such studies can admittedly reveal only the irretrievable end products of disease; yet from such determinations it has not infrequently been possible to explain the clinical manifestations of a given entity and to discern its consecutive steps to the fatal termination. In more recent years other allied sciences have lent their impetus to the advance of clinical medicine; but the clinico-pathologic orientation still constitutes one of the most
MIDDLETON WS. Syphilitic Aortitis in Retrospect12. Ann Intern Med. ;5:294–306. doi: 10.7326/0003-4819-5-3-294
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Published: Ann Intern Med. 1931;5(3):294-306.
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