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Barbital (diethyl barbituric acid), phenobarbital (ethyl-phenyl), nembutal (ethyl-secondary amyl) and pernocton (B-bromallyl secondary butyl) were all found to possess the life-saving antagonistic action to strychnine poisoning which Zerfas and McCallum demonstrated for amytal (ethylisomyl barbituric acid). By starting the administration of these drugs with the onset of convulsions it was found possible to save the lives of rabbits which had received strychnine in an amount in excess of the certain lethal dose. Phenobarbital was much more effective than barbital when judged by the amount of the drug necessary to control convulsions.
Suppression of Strychnine Convulsions by Barbiturates.. Ann Intern Med. 1931;5:390. doi: 10.7326/0003-4819-5-3-390_3
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Published: Ann Intern Med. 1931;5(3):390.
Neurology, Seizure Disorders.
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