JAMES B. CAREY, M.D., F.A.C.P.; JOSEPH H. TAYLOR, M.D.
There are various toxic and chemical agents, which may so affect the bone marrow that it is incapable of forming blood elements, and a condition of profound anemia may therefore occur. Infectious diseases, which progress to severe stages of toxicity or septicemia; benzol; trinitrotoluene; arsenic; roentgen rays and radium emanations can all affect the hematopoietic system in such a manner as to produce the clinical picture of an aplastic anemia. In certain chronic blood disorders and malignancy, there often occurs an exhaustive aplasia of the blood-forming tissues.
Excluding all known etiologic factors, however, there remains the primary or idiopathic case.
CAREY JB, TAYLOR JH. Primary Aplastic Anemia; A Discussion and Report of Two Cases(Primary Aplastic Anemia; A Discussion and Report of Two Cases*†)(Primary Aplastic Anemia; A Discussion and Report of Two Cases*†). Ann Intern Med. 1931;5:471–477. doi: 10.7326/0003-4819-5-4-471
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Published: Ann Intern Med. 1931;5(4):471-477.
Hematology/Oncology, Red Cell Disorders.
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