HAROLD A. BULGER, M.D.; DAVID P. BARR, M.D., F.A.C.P.
The profound influence of the parathyroid glands on calcium metabolism is apparent from both experimental and clinical studies. Removal of these glands results in a marked decrease in serum calcium, tetany, and in retention of calcium in the body. By means of the parathyroid extract of Collip12 it is possible not only to relieve the tetany but also to restore approximately normal conditions of calcium metabolism. Large doses of parathormone cause, in normal animals, hypercalcemia, hypotonicity of muscles, a great increase in the excretion of calcium in the urine, a deposit of calcium in the tissues, and decalcification of bone.
BULGER HA, BARR DP. The Relation of the Parathyroid Glands to Calcium Metabolism(The Relation of the Parathyroid Glands to Calcium Metabolism*†)(The Relation of the Parathyroid Glands to Calcium Metabolism*†). Ann Intern Med. 1931;5:552–565. doi: 10.7326/0003-4819-5-5-552
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Published: Ann Intern Med. 1931;5(5):552-565.
Endocrine and Metabolism, Parathyroid Disorders.
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