MAYNARD E. HOLMES, M.D., F.A.C.P.
The term hyperthyroidism has been adopted in recent years to designate a symptom complex caused by hyperactivity of the thyroid gland. In the past, patients who are now classified as having hyperthyroidism together with a large group with a similar symptomatology but not of thyroid origin, were diagnosed as having Graves' disease. Kessel1 has called attention to the latter group and applied to it the term autonomic imbalance, to designate it as a disturbance of the autonomic nervous system.
Moschcowitz2 is of the opinion that Graves' disease evolves from a basic neuropathic personality to its fullblown clinical form when hyperthyroidism
HOLMES ME. The Diagnosis of Hyperthyroidism(The Diagnosis of Hyperthyroidism*†)(The Diagnosis of Hyperthyroidism*†). Ann Intern Med. 1932;5:1028–1032. doi: 10.7326/0003-4819-5-8-1028
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Published: Ann Intern Med. 1932;5(8):1028-1032.
Endocrine and Metabolism, Thyroid Disorders.
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