In a paper which was not published until after his death, Warthin1 described the occurrence of large multinucleate giant cells in the tonsils of four patients who subsequently developed measles. In each instance, as afterwards appeared, tonsillectomy had been performed from twenty-four to ninety-six hours before the appearance of the exanthem. So characteristic were the histopathological findings that they were used successfully in the later cases of the series to predict the onset of measles before clinical evidence was available. One child was removed from an open ward and placed under contagious disease precautions on the strength of the pathological
THE LYMPHOID TISSUE CHANGES IN THE PRODROMAL STAGE OF MEASLES. Ann Intern Med. ;5:1039–1040. doi: 10.7326/0003-4819-5-8-1039_2
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Published: Ann Intern Med. 1932;5(8):1039-1040.
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