L. R. HIMMELBERGER, Ph.D.
While the terms Graves' disease, Basedow's disease and exophthalmic goiter are purely clinical expressions and their use in pathological connections perhaps questionable, no suitable pathological term exists that is descriptive of the changes seen in the thyroid gland in this disease. Parenchymatous hypertrophy and hyperplasia have been used quite properly but these expressions do not describe the most important changes seen, as we hope to show. The present clinical tendency to consider "toxic adenoma" as a condition separate from Graves' or Basedow's disease also lends confusion to a pathological understanding of the process in the thyroid gland.
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HIMMELBERGER LR. The Significance of Lymphatic Tissue and Adenoma-Like Areas in the Thyroid Gland123. Ann Intern Med. ;5:1404–1420. doi: 10.7326/0003-4819-5-11-1404
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Published: Ann Intern Med. 1932;5(11):1404-1420.
Endocrine and Metabolism, Hematology/Oncology, Thyroid Disorders.
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