HOWARD B. LEWIS, Ph.D.
Cystinuria has been considered a relatively rare error of metabolism. Since the report of the first cystine calculus of the urinary tract by Wollaston in 1810, the number of observed cases has been surprisingly small. Kretschmer,1 in a review of the occurrence of cystine calculi written in 1916, was able to find reports of only 107 cases of cystine calculi in a period of more than a century since Wollaston's original observation. The present author has reviewed elsewhere2 the literature since 1920 and has summarized 71 cases of cystinuria, although calculus formation had not been observed in all of these.
LEWIS HB. The Occurrence of Cystinuria in Healthy Young Men and Women12. Ann Intern Med. ;6:183–192. doi: 10.7326/0003-4819-6-2-183
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Published: Ann Intern Med. 1932;6(2):183-192.
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