HOBART A. REIMANN, M.D.
Fever, one of the most constant and striking features characteristic of the invasion and growth of pathogenic microörganisms, has attracted the attention of physicians since the beginning of medicine. Hippocrates, Celsus, Sydenham and many others considered it of importance as a defensive mechanism against disease, "vis medicatrix naturae". This viewpoint prevailed generally until the nineteenth century when a number of observers took an opposite stand. Claude Bernard, Liebermeister and others devoted much attention to fever and believed it to be harmful. Their opinion in regard to the deleterious effect of fever on the body appeared to be greatly enhanced by
HOBART A. REIMANN. The Significance of Fever and Blood Protein Changes in Regard to Defense Against Infection. Ann Intern Med. 1932;6:362–374. doi: 10.7326/0003-4819-6-3-362
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Published: Ann Intern Med. 1932;6(3):362-374.
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