WARD DARLEY, M.D.; RICHARD W. WHITEHEAD, M.D.
The literature prior to 1919 dealing with the antigenic properties of protein cleavage products has been thoroughly reviewed by Fink.1 He briefly summarizes the numerous papers reviewed by stating that experiments with products of protein digestion show that proteins cannot be disintegrated much, if any, beyond the coagulable form without losing their sensitizing properties. By experiments in which he prepared proteoses from egg albumin he demonstrated that proteoses have definite antigenic properties. Auld,2 in 1917, began to advocate the use of non-specific peptone therapy in the treatment of bronchial asthma and since that time he has published numerous papers on
DARLEY W, WHITEHEAD RW. Studies on a Urinary Proteose: II. Skin Reactions and Therapeutic Applications in Hay Fever. Ann Intern Med. ;6:389–399. doi: 10.7326/0003-4819-6-3-389
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Published: Ann Intern Med. 1932;6(3):389-399.
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