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A 25 per cent colloidal solution of thorium dioxide ("Thorotrast") when injected intravenously into rabbits was found to circulate for about five minutes in the colloidal state and then to flocculate. The flocculated particles were engulfed, for the most part, by the reticulo-endothelium of the liver, spleen, other lymphoid tissues, and bone marrow, and by parenchymatous cells of the liver. Thus fixed in a finely divided state, the thorium dioxide in the liver and spleen produced a shadow permitting the visualization of these organs. The shadow cast by bone marrow was obscured by the covering bone. With large doses the
The Experimental Intravenous Administration of Colloidal Thorium Dioxide.. Ann Intern Med. ;6:706–707. doi: 10.7326/0003-4819-6-5-706_3
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Published: Ann Intern Med. 1932;6(5):706-707.
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