D. SCHUYLER PULFORD, M.S., M.D., F.A.C.P.
It is my purpose to outline the present status of the ketogenic diet rather than urge its use or disprove its value by reporting results on 75 treated cases of epilepsy. Sufficient time has now elapsed since Wilder's1 introduction of this low carbohydrate high fat diet in 1921 to estimate its worth.
Ketosis is physiologically different from acidosis caused by a shift in acid base equilibrium and has other effects than dehydration. Therefore, in spite of the brilliant results of Fay2 and McQuarrie3 and their followers with fluid restriction, diet-produced ketosis still commands our attention.
PULFORD DS. The Present Status of the Ketogenic Diet. Ann Intern Med. ;6:795–801. doi: 10.7326/0003-4819-6-6-795
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Published: Ann Intern Med. 1932;6(6):795-801.
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