E. M. WATSON, M.D., F.R.C.P.; W. S. DICK, M.D., M.Sc.
Recent investigations have pointed to the existence in the blood of a substance which is capable of inhibiting the activity of insulin. Karelitz, Cohen, and Leader,1 as the outcome of an attempt to discover the cause of insulin resistance in a patient with diabetes mellitus, observed that the blood of diabetics, and to a lesser extent that of normal persons, apparently possessed something which was antagonistic in its action to insulin. While this inhibiting property was demonstrated by blood plasma, it was exhibited to a more marked degree by laked red blood cells. Their data were elicited by studying the
WATSON EM, DICK WS. Some Observations Concerning a Possible Insulin-Inhibiting Substance in Urine12. Ann Intern Med. ;6:1171–1179. doi: 10.7326/0003-4819-6-9-1171
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Published: Ann Intern Med. 1933;6(9):1171-1179.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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