JOHN E. WALKER, M.D., F.A.C.P.
Hypochromic anemia in adults is generally considered as secondary to some other disease process, such as hemorrhage, malignancy, infection, or nephritis. This view has prevailed so long that "hypochromic anemia" and "secondary anemia" are often used as synonymous terms. In recent years, however, a type of hypochromic anemia has been recognized as an independent disease. The condition may be referred to as primary hypochromic anemia. It occurs almost exclusively in women. Achlorhydria is nearly always present. One of the most characteristic features of the disease is a rapid, almost dramatic, response to iron therapy in massive doses. Its recognition is
WALKER JE. Primary Hypochromic Anemia1: Its Importance in Medical and Surgical Diagnosis. Ann Intern Med. 1933;6:1434–1440. doi: 10.7326/0003-4819-6-11-1434
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Published: Ann Intern Med. 1933;6(11):1434-1440.
Hematology/Oncology, Red Cell Disorders.
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