ROGER S. MORRIS, F.A.C.P.; MURRAY L. RICH; LEON SCHIFF; JOHN H. FOULGER; HENRY FELSON
It has been demonstrated1,2 that the normal stomach in man, swine, dogs and cattle secretes an hemopoietic substance which, when properly concentrated and purified, may be injected intramuscularly into man. This substance is thermolabile, dialyzable through collodion, and exhaustible, and may be converted to an ethyl ester and extracted with non-aqueous solvents (ether, acetone, chloroform) without impairing its hemopoietic activity. These properties, which characterize both the material obtained from human gastric juice and that from the gastric contents of swine, practically exclude the possibility of its being an enzyme. It is probable that it is a physiological hemopoietic hormone, for
MORRIS RS, RICH ML, SCHIFF L, FOULGER JH, FELSON H. Observations on Addisin in Diseases of the Blood12. Ann Intern Med. ;6:1535–1545. doi: 10.7326/0003-4819-6-12-1535
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Published: Ann Intern Med. 1933;6(12):1535-1545.
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