FRANK A. HARTMAN, PH.D.
A careful consideration of the functions of cortin should precede its clinical application.
From a study of clinical material and animal experiments certain functions of cortin are indicated. We propose to discuss these together with findings which may bear on other functions not clearly indicated. The symptoms pathognomonic of Addison's disease—asthenia, gastrointestinal instability and pigmentation—may give us clues to follow in our hunt for the function or functions of cortin. Of these asthenia is outstanding.
Usually this is the first symptom to appear. It develops so insidiously that the subject may not be able to date its first appearance
HARTMAN FA. STUDIES ON THE FUNCTION AND CLINICAL USE OF CORTIN1. Ann Intern Med. ;7:6–22. doi: 10.7326/0003-4819-7-1-6
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Published: Ann Intern Med. 1933;7(1):6-22.
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