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The wave of so-called ginger paralysis which occurred in several parts of the United States in 1930 interested the Institute of Health in the investigation of the toxicological and pharmacological nature of the phosphoric acid ester of ortho-cresol. This substance had been used as an adulterant in the extracts of ginger responsible for the poisoning.
In an effort to establish the relation of chemical constitution and physiological activity, the investigators examined twelve esters related to ortho-cresol-phosphate. The formulas and certain physical constants of the compounds are set forth in the publication.
Various types of laboratory animals were used in the
Further Studies on the Pharmacology of Certain Phenol Esters with Special Reference to the Relation of Chemical Constitution and Physiologic Action. The Histopathology of Some Neurotoxic Phenol Esters.. Ann Intern Med. ;7:274–275. doi: 10.7326/0003-4819-7-2-274
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Published: Ann Intern Med. 1933;7(2):274-275.
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