WILDER PENFIELD, M.D., F.R.C.S.C.
The mechanism of so prevalent a curse as epilepsy must necessarily interest every physician. The suggestion that vasoconstriction plays a rôle in the spread of an epileptic discharge is to be found in the prescient writings of Hughlings Jackson1 and he himself reported vasoconstriction in retinal arteries during an epileptic seizure. Spielmeyer2 has found histological evidence of recurring vasospasm in the brains of epileptic patients. Foster Kennedy reported visible shrinking of the brain in an epileptic attack seen at the operating table and Foerster,3 who has observed many fits during intracranial operations, reports that the brain shrinks, then expands enormously
PENFIELD W. THE EVIDENCE FOR A CEREBRAL VASCULAR MECHANISM IN EPILEPSY1. Ann Intern Med. 1933;7:303–310. doi: 10.7326/0003-4819-7-3-303
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Published: Ann Intern Med. 1933;7(3):303-310.
Neurology, Seizure Disorders.
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