DUNCAN GRAHAM, M.B.(Tor.), F.R.C.P.(C.)
Clinicians have long recognized that certain conditions, usually of a chronic nature, which affect the extremities and commonly terminate in gangrene, result from insufficient circulation. With the demonstration by Raynaud that gangrene could develop without vascular occlusion, these conditions were divided into two groups: (1) those due to structural disease of the arteries, described and classified under the general term arteriosclerosis; (2) those due to functional disturbance of the arteries without structural change: for example, Raynaud's disease. The accepted neurogenic origin of the vascular disturbance in Raynaud's disease and in the condition described later by Weir Mitchell as erythromelalgia and
GRAHAM D. CHRONIC ARTERIAL OCCLUSION OF THE EXTREMITIES1. Ann Intern Med. ;7:431–438. doi: 10.7326/0003-4819-7-4-431
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Published: Ann Intern Med. 1933;7(4):431-438.
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