SAMUEL PERLOW, M.D.
In 1927 Thomas Lewis1 demonstrated that the histamine skin reaction consisted of three distinct factors, (1) a local dilatation of the capillaries, venules, and arterioles by direct action which caused a purplish areola, (2) a local increase in the permeability of the walls of the minute vessels by direct action, which caused a wheal at the site of the injection, and (3) a widespread dilatation of the surrounding arterioles by local reflex action, which was visible as a red flare. He also demonstrated that if the circulation was cut off completely a purple spot would appear but no wheal or
PERLOW S. A PAINLESS HISTAMINE SKIN TEST: AN EXPERIMENTAL STUDY1. Ann Intern Med. ;7:561–565. doi: 10.7326/0003-4819-7-5-561
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Published: Ann Intern Med. 1933;7(5):561-565.
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