L. W. DIGGS, M.D.; C. F. AHMANN, PH.D.; JUANITA BIBB, A.B.
If one takes a drop of blood from each member of an unselected series of negroes, seals the drops under cover-slips, and examines them microscopically over a period of hours, he observes striking curved and pointed distortions of the erythrocytes in an appreciable number of the preparations. (Figure 1.) Erythrocytes assuming such bizarre stellate shapes are called "sickled cells" and individuals whose erythrocytes are capable of undergoing such a metamorphosis under suitable conditions are said to possess the "sickle cell trait." The anomaly is hereditary and is thought to be transmitted as a dominant Mendelian characteristic. Within the large group
DIGGS LW, AHMANN CF, BIBB J. THE INCIDENCE AND SIGNIFICANCE OF THE SICKLE CELL TRAIT(THE INCIDENCE AND SIGNIFICANCE OF THE SICKLE CELL TRAIT*). Ann Intern Med. 1933;7:769–778. doi: 10.7326/0003-4819-7-6-769
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Published: Ann Intern Med. 1933;7(6):769-778.
Hematology/Oncology, Red Cell Disorders.
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