BAYARD T. HORTON, M.D., F.A.C.P.; FRANK N. ALLAN, M.D., F.A.C.P.
Gangrene of the lower extremities in cases of diabetes is due primarily to impairment of circulation and secondarily to the effects of the diabetes on the resistance of the skin to infection. In cases of long standing, without adequate treatment, arteriosclerosis is common. It develops early in life and to a more advanced degree than in nondiabetic patients. In some cases, however, the occlusive process is of a different type. The present report, with the exception of a case reported by Adams in 1930, includes all cases of thromboangiitis obliterans complicated with diabetes observed at The Mayo Clinic. The small
HORTON BT, ALLAN FN. THROMBOANGIITIS OBLITERANS OF PATIENTS WITH DIABETES1. Ann Intern Med. ;7:799–804. doi: 10.7326/0003-4819-7-7-799
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Published: Ann Intern Med. 1934;7(7):799-804.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Rheumatology.
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