RUSSELL M. WILDER, M.D.; GEORGE M. HIGGINS, PH.D.; CHARLES SHEARD, PH.D.
The earliest suggestion of a correlation between the function of the parathyroid glands and rickets is to be found in a contribution of Erdheim2 in 1906. Extirpation of the parathyroid glands of young rats led to decalcification of the dentin of the incisor teeth and to dental abnormalities resembling those found in spontaneous rickets of rats. In the normal rats, after parathyroidectomy, an increased amount of osteoid tissue developed, especially in the ribs; fractures occurred and the deposit of calcium in the calluses of the fractures was deficient. A cartilage typical of rickets was not seen, but this discrepancy was
WILDER RM, HIGGINS GM, SHEARD C. THE SIGNIFICANCE OF THE HYPERTROPHY AND HYPERPLASIA OF THE PARATHYROID GLANDS IN RICKETS AND OSTEOMALACIA1. Ann Intern Med. ;7:1059–1069. doi: 10.7326/0003-4819-7-9-1059
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Published: Ann Intern Med. 1934;7(9):1059-1069.
Endocrine and Metabolism, Metabolic Bone Disorders, Parathyroid Disorders.
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