PHILIP S. HENCH, M.D., F.A.C.P.
In the last four years I have observed a number of patients whose pain, caused by arthritis, fibrositis or sciatica, was markedly, usually completely, relieved coincident with the appearance of intrahepatic jaundice. In two cases the jaundice apparently was not induced by any drug; in the other cases it resulted from cinchophen. However, the analgesia was not caused by the cinchophen, as will appear.
Cases of "cinchophen hepatitis" afford opportunities for studying analgesia associated with icterus, for the cinchophen is generally taken for a chronic type of pain, usually that of long standing "rheumatism." Two particularly striking examples of the
HENCH PS. THE ANALGESIC EFFECT OF HEPATITIS AND JAUNDICE IN CHRONIC ARTHRITIS, FIBROSITIS AND SCIATIC PAIN1. Ann Intern Med. ;7:1278–1294. doi: 10.7326/0003-4819-7-10-1278
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Published: Ann Intern Med. 1934;7(10):1278-1294.
Chronic Fatigue Syndrome/Fibromyalgia, Gastroenterology/Hepatology, Liver Disease, Rheumatology.
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