J. B. COLLIP, F.A.C.P.
It has been a matter of great interest to those working in endocrinology to note in the case of many laboratory animals and also in the case of many patients, that a state of lowered reactivity, of increased resistance or of actual non-responsiveness may gradually become manifested in those that have been treated for a long period with some glandular extract. Likewise, it has been observed that certain previously untreated animals or patients may be non-responsive to injections of a known potent glandular extract. We have only to think of the failure of the parathyroid hormone to affect appreciably the
COLLIP JB. INHIBITORY HORMONES AND THE PRINCIPLE OF INVERSE RESPONSE1. Ann Intern Med. ;8:10–13. doi: 10.7326/0003-4819-8-1-10
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Published: Ann Intern Med. 1934;8(1):10-13.
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